Proton Pump Inhibitor Lawsuits: Heartburn Drugs Linked To Kidney Disease

Proton Pump Inhibitor Lawsuits: Heartburn Drugs Linked To Kidney Disease 2018-08-14T15:58:55+00:00
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Rosen Injury Lawyers is currently accepting and investigating lawsuits against the manufacturers of various proton pump inhibitors including Nexium, Prilosec, Prevacid, Dexilant, and Zegerid. Did you suffer:

  • Acute Kidney Injury?
  • AIN or Acute Interstitial Nephritis?
  • Kidney Failure or Chronic Kidney Disease?

Trust us to review your situation thoroughly and evaluate your legal options.

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We believe these drugs were marketed illegally to consumers.

— Laurence Rosen, Esq.

Rosen Injury Lawyers is currently accepting and investigating lawsuits against the manufacturers of various proton pump inhibitors including Nexium, Prilosec, Prevacid, Dexilant, and Zegerid. Did you suffer:

  • Acute Kidney Injury?
  • AIN or Acute Interstitial Nephritis?
  • Kidney Failure or Chronic Kidney Disease?

Trust us to review your situation thoroughly and evaluate your legal options.

24/7 Free PPI Consultations

(866) 807-4631

We believe these drugs were marketed illegally to consumers.

— Laurence Rosen, Esq.
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In hundreds of product liability lawsuits, patients across the country claim to have suffered severe kidney injuries after taking a proton pump inhibitor (PPI) drug. To date, consumers have filed suit over a wide range of heartburn drugs, all of which have been linked to a serious risk for chronic kidney PPIsdisease and kidney failure:

  • Nexium - AstraZeneca
  • Prevacid - Takeda Pharmaceuticals
  • Prilosec - Procter & Gamble
  • Dexilant - Takeda Pharmaceuticals
  • Zegerid - Bayer

If you or a loved one took a proton pump inhibitor drug and suffered kidney side effects, you may be eligible to pursue financial compensation.

Proton Pump Inhibitors: Did Drug Companies Fail To Warn?

PPI lawsuits accuse pharmaceutical manufacturers of disregarding medical evidence with the sole aim of increasing corporate profits.

Over the last three years, a growing body of scientific research has drawn a direct link from the world's most popular heartburn drugs, including Nexium and Prevacid, to debilitating forms of kidney disease. The companies behind these medications, however, have failed to warn the public of these newly-identified risks, plaintiffs say.

Long-Term PPI Use Poses Serious Risks

Proton pump inhibitors are wildly popular. Available both by prescription and over-the-counter, medications including Nexium, Prilosec and Prevacid are now used by around 1 out of every 20 people in the developed world. The drugs work by reducing the amount of gastric acid secreted in the stomach, thus providing relief for people who have a wide range of gastrointestinal conditions:

  • dyspepsia (heartburn)
  • stomach ulcers
  • Zollinger-Ellison syndrome

In recent years, however, PPI drugs have become an increasingly-common treatment for chronic conditions, most notably gastroesophageal reflux disease (GERD). That could be a major problem.

Side Effects & Complications

Over-the-counter PPI formulations are only designed to be used for a limited amount of time, usually a 14-day-course no more than three times a year. There's a good reason for this guideline. Long-term use of proton pump inhibitors has been linked to a host of serious medical complications.

In 2010, the US Food & Drug Administration warned patients and medical providers that PPI use lasting longer than a year, or at higher dosages, could increase the risk for bone disorders, including osteoporosis, and associated bone fractures.

Then, two years later, another risk emerged. Proton pump inhibitors, the FDA said, could leave patients vulnerable to Clostridium difficile, an infectious bacterium that can cause long-lasting diarrhea. As it turns out, decreasing the levels of gastric acid in the intestines isn't always a good thing, since that acid can be helpful to knock out infectious agents.

Gastric acid is also beneficial in breaking down the foods we eat. That's why PPI drugs have also been associated with vitamin and mineral deficiencies; these medications reduce your body's ability to make use of the nutrients in our food.

Alleged Risks To Kidney Health

The most serious potential risk of PPI use, however, is almost undoubtedly kidney disease. A series of recent studies have found that patients who take a PPI drug may be significantly more likely to develop chronic kidney disease and, ultimately, experience kidney failure.

This isn't breaking news. In fact, researchers have been worried about the effect that PPI drugs can have on kidney function for decades. Around 20 years ago, patients began to report symptoms of acute interstitial nephritis, in which portions of the kidney begin to swell. Usually the result of an allergic reaction, acute interstitial nephritis requires immediate treatment to prevent long-term kidney damage.

In 2014, the FDA forced every proton pump inhibitor manufacturer to add a warning to their drugs' label, notifying patients that "acute interstitial nephritis has been observed in patients taking PPIs."

Chronic Kidney Disease & Acute Kidney Injuries

More recent studies have expanded our understanding of the kidney risks.

A study of 10,482 patients from researchers at Johns Hopkins and Yale found that people who take PPI drugs are between 20% and 50% more likely to develop chronic kidney disease (CKD), a gradual deterioration in kidney function.

Acute kidney injuries, a sudden-onset form of kidney failure, may be over twice as common in PPI patients than people who don't take the drugs.

Lawsuits Claim Failure To Warn

Yet no PPI manufacturer even mentions chronic kidney disease or acute kidney injuries (AKD) in drug warning labels. As one plaintiff alleged in his 2017 Nexium lawsuit, "despite clear knowledge that [PPI drugs] cause a significantly increased risk of CKD, AKI and other renal impairment, [drug manufacturers] continue to market and sell Nexium without warning consumers or healthcare providers of the significant risks to the kidney."

Needless to say, AstraZeneca, Procter & Gamble and Takeda Pharmaceuticals categorically deny that they have failed to warn the public of PPI's link to kidney disease.

MDL Consolidation In New Jersey

To date, nearly 700 patients have filed proton pump inhibitor lawsuits of their own, drawing pharmaceutical manufacturers from AstraZeneca to Wyeth Pharmaceuticals into court. The vast majority of these cases are now consolidated in the US District Court of New Jersey. And, importantly, the Multi-District Litigation established in Newark includes lawsuits filed against a variety of manufacturers.

Under the guidance of District Judge Claire C. Cecchi, cases filed over Nexium and Prilosec are joined by claims involving lesser-known PPI products like Dexilant, manufactured by Japanese firm Takeda. Together, plaintiffs will now move through pre-trial proceedings as a group.



Proton Pump Inhibitor Lawsuit News

Laurence Rosen, Esq. - PPI Lawyer
Proton pump inhibitor drugs, used to treat heartburn around the world, may cause severe complications, including kidney disease and esophageal cancer. In our news and breaking updates section, you'll find all the latest developments on PPI medications and their risks.

June 29, 2018 - New Study Reports Increase In Gastrointestinal Cancer Risk Among Proton Pump Inhibitor Patients

A group of researchers in Hong Kong say they have found a link between proton pump inhibitor drugs and an increased risk for gastrointestinal cancer. In a paper for the peer-reviewed journal Gut, Dr. K.S. Cheung and co-authors report a 244% rise in the risk for stomach and intestinal cancers among patients who had been prescribed a proton pump inhibitor to help tackle H. pylori, a bacterial infection that attacks intestinal cells. Patients who took an H2-antagonist drug, on the other hand, were observed to have a decreased risk for gastrointestinal cancers, the researchers write. To find more on the research, follow this link.

May 3, 2018 - Researchers Find 25% Increased Risk Of Death In PPI Drug Patients

A team of public health researchers at Washington University in St. Louis have discovered a link between proton pump inhibitors and an increased risk of death. Analyzing patient medical records from the Department of Veterans Affairs, the group found that, compared to people who take H2 blockers, PPI patients may live at a 25% increased risk of death. "The results were clear," says lead author Dr. Ziyad Al-Aly. To learn more about the research, click here.

April 26, 2018 - Proton Pump Inhibitors May Increase Pneumonia Risk In Older Patients, Study Finds

The world's most popular heartburn drugs have been linked to an increased risk for pneumonia in elderly patients, Healio reports. Looking at patients older than 60 years, researchers at the University of Exeter Medical School in England discovered that people who had been taking proton pump inhibitors for at least two years were around 82% more likely to develop pneumonia than their peers. Proton pump inhibitors, known for their ability to reduce the painful symptoms of gastroesophageal reflux disease in short-term courses of treatment, are often prescribed for long-term usage, despite significant risks. To learn more about the research linking proton pump inhibitor drugs, like Nexium and Prevacid, to kidney disease, click here.

March 26, 2018 - Swedish Study Shows Association Between Heartburn Meds & Esophageal Cancer

A new study has found a link between proton pump inhibitors and esophageal cancer. In their research, scientists from Sweden discovered that, among millions of studied patients, people who had been prescribed a proton pump inhibitor were around 250% more likely to develop esophageal cancer. That increased risk skyrocketed to nearly 800% when the researchers considered only PPI patients who took the drugs daily for substantial periods of time. For more on the study, follow this link.

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